A granuloma is a small area of inflammation in tissue due to injury, such as from an infection. Typically, granulomas cause no signs or symptoms and are usually found through an X-ray that is performed for an unrelated reason. Granulomas are benign (noncancerous), although they may be mistaken for cancer on an X-ray.
The most common cause of granuloma is histoplasmosis, a fungal infection that primarily affects the lungs. Other conditions associated with a granuloma formation include berylliosis, syphilis, sarcoidosis, Crohn's disease, tuberculosis, Churg-Strauss syndrome, and Wegener's granulomatosis.
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