Blistering diseases are characterized by large (>1 cm) blisters, or bullae, on the skin. These fluid-filled lesions are usually caused by inflammation in or under the surface layer of skin, called the epidermis. Other symptoms may include rashes, itchy or red patches, sores, pain or swelling. Blistering diseases include pemphigus and bullous pemphigoid, contact dermatitis, erythema and erythroderma, impetigo and staphylococcal scalded skin syndrome. Blisters are also common symptoms in patients with viral or bacterial infections, herpes, diabetes or some autoimmune disorders. Treatment of blistering diseases varies depending on the specific condition but is generally geared toward relieving symptoms, reducing inflammation with the use of topical steroids or immunosuppressants and preventing or treating any infections that occur.
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